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Aplastic Anaemia

Aplastic Anaemia - Causes and Risk Factors

What causes aplastic anaemia? 

Most aplastic anaemia cases are due to suppression of the bone marrow by the immune system. 

A small minority of cases may be due to genetic predisposition or medications and toxins. Other causes can include:
  • Viral infections: Certain viruses, such as hepatitis, Epstein-Barr virus and HIV, can lead to aplastic anaemia by damaging the bone marrow.

  • Radiation and chemotherapy: Treatment for cancer and other conditions can harm the bone marrow, potentially leading to aplastic anaemia.

What are the risk factors for aplastic anaemia?

  • Autoimmune conditions: People with autoimmune disorders like lupus may be at higher risk due to immune system dysregulation.

  • Exposure to industrial chemicals: Contact with chemicals like benzene or pesticides can increase the risk of developing aplastic anaemia.

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

Our Care Team

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Jason Chay Wai Mun Dr

Dr Jason Chay Wai Mun

Senior Consultant

​MBBS (Singapore), MRCP (UK), FRCPath Haematology (UK), FAMS (Singapore), GDFM (Singapore)

Clinical Interests: Transfusion Medicine, Laboratory Haematology

Denise Tan Yan Dr

Dr Denise Tan Yan

Senior Consultant

MBBS (Singapore), MRCP (UK), MMed (Internal Medicine), FRCPath (UK)

Clinical Interests: General Haematology, Myeloproliferative Neoplasm

Tan Yan Chin Dr

Dr Tan Yan Chin

Consultant

​MD(UKM), MMed(NUS), MRCP(UK), FRCPath(UK)

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